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Imugene begins manufacture of its innovative cancer vaccine for trials

Proactive Investors Sunday, 23 September 2018
Imugene Limited (ASX:IMU) has formally commenced cGMP (current good manufacturing practice) manufacture of the clinical batch of its cancer vaccine KEY-Vaxx. The cGMP batch is part of the pre-clinical development for the proposed PD-1 phase I clinical trial to be conducted in 2019. AmbioPharm Inc, a US-based peptide manufacturing company has been appointed to manufacture the vaccine. We've commenced cGMP manufacturing of the clinical batch of cancer vaccine KEY-Vaxx for the proposed Phase 1 PD-1 clinical trial, after successfully completing pilot studies. AmbioPharm Inc. (APi), a US-based cGMP manufacturer has been appointed $IMU #ASX — Imugene Ltd (@TeamImugene) September 20, 2018 KEY-Vaxx is a B-cell peptide cancer vaccine which aims to induce the body to produce polyclonal antibodies that block PD-1 signalling, and potentially produce an anticancer effect similar to Keytruda, Opdivo and the other immune checkpoint inhibitor monoclonal antibodies that are transforming the treatment of a range of cancers. KEY-Vaxx has shown potential in preclinical studies, outperforming an industry-standard antibody in a mouse model of HER2+ colorectal cancer. New provisional patent The protection of Imugene’s global position in PD-1 B-cell cancer vaccines has been strengthened with the filing of a new provisional patent in Australia titled “A vaccine composition and uses thereof”. READ: Imugene signs exclusive, world-widelicence for cancer vaccine Imugene managing director Leslie Chong said: “Maintaining and strengthening our already strong international intellectual property position is a key area of focus in maintaining the competitive advantage of KEY-Vaxx and any future improvements, vaccine formulations and clinical uses. “We are extremely pleased with the progress made from our expert scientific team.”
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