Australia  

Celebrating 10 Years of Trusted News Discovery
One News Page
> >

Kazia Therapeutics' cancer drug trials lift valuation to $137 million or $2.20 a share, according to Edison

Proactive Investors Monday, 9 September 2019 ()
Kazia Therapeutics Ltd (ASX:KZA) has had its valuation updated to A$137 million or A$2.20 a share by Edison Investment Research Limited, which maintains its base case scenario of a 2024 launch for Kazia's brain cancer drug GDC-0084. The report also suggests an alternative delayed scenario of a 2026 launch with an adjusted value of A$86 million or A$1.38 a share. It estimated about A$15-20 million will be needed to fund the GDC-0084 phase-2b and phase-three studies that could start in 2020 and progression of ovarian cancer treatment Cantrixil is assumed to require a partner. Edison says that initial data of the current GDC-0084 phase-two study, if positive, could trigger a phase-2b randomised study and potential partnering by 2023. The following is an extract from the report: Efficacy indications for GDC-0084 by late 2019 Kazia is recruiting a 20-patient expansion cohort in its current GDC-0084 phase II study at a 60 milligram dose – higher than the 45 milligram used by Genentech. GDC-0084 has a provisionally assigned official name, paxalisib, subject to final confirmation. The initial data may be available by Q419. If positive, this could trigger a phase-2b randomised study and potential partnering by 2023. We assume as our base case scenario that this might be adequate for approval in 2024 as patients resistant to the current standard therapy, temozolomide, have no other therapies available. New metastatic trial for GDC-0084 with radiotherapy Memorial Sloan Kettering Cancer Center (MSK) in New York supported by Kazia will lead a phase-one trial of GDC-0084 combined with radiotherapy to treat solid brain metastases with a genetic alteration. This has a dose ranging phase followed by cohort expansion. It may report data in H221. The PI3K pathway inhibited by GDC-0084 enables cells damaged by radiation to survive rather than enter apoptosis (cell death) so blocking PI3K might boost the efficacy of radiotherapy. Cantrixil efficacy indications possible by late 2019 Cantrixil is also in a cohort expansion stage with 12 patients recruited and data due in Q4. Initial data in April was very promising, with one partial responder and five stable disease patients treated. Cantrixil, an intra-peritoneal injection of a novel cytotoxic agent, could become a standard treatment for third-line ovarian cancer patients who now have few therapy alternatives and very poor prognosis.
0
shares
ShareTweetSavePostSend
 
Credit: Wibbitz Studio - Published < > Embed
News video: Cancer Is Now the Leading Cause of Death in Several Countries

Cancer Is Now the Leading Cause of Death in Several Countries 01:00

Cancer Is Now the Leading Cause of Death in Several Countries. According to new research published in the journal ‘The Lancet,’ deaths caused by cancer are more common than by heart disease in high-income countries. We are seeing a new epidemiologic transition - from heart disease to cancer as...

Recent related videos from verified sources

A Stage 4 Cancer Survivor's Journey [Video]A Stage 4 Cancer Survivor's Journey

In 2012, Sarah Kaehny was diagnosed with stage 4 sarcoma, the same cancer that killed her father. Over the next several years, she had 8 surgeries and chemotherapy. Then the doctors at Froedtert and..

Credit: TODAY’S TMJ4     Duration: 06:42Published

A Stage 4 Cancer Survivor's Journey [Video]A Stage 4 Cancer Survivor's Journey

In 2012, Sarah Kaehny was diagnosed with stage 4 sarcoma, the same cancer that killed her father. Over the next several years, she had 8 surgeries and chemotherapy. Then the doctors at Froedtert and..

Credit: Rumble     Duration: 06:42Published


Recent related news from verified sources

Kazia Therapeutics wins ANZLF Trans-Tasman Innovation and Growth award

Kazia Therapeutics Ltd (ASX:KZA) is a winner in the 2019 Australian and New Zealand Leadership Forum (ANZLF) Trans-Tasman Innovation and Growth Awards presented...
Proactive Investors

Blackham Resources has a new substantial shareholder in Delphi; share purchase plan opens

Blackham Resources Ltd (ASX:BLK) has had Germany-based Delphi become a major shareholder in the company with a 7.08% holding. The new stake includes 300 million...
Proactive Investors

You Might Like

Environmentally friendly: One News Page is hosted on servers powered solely by renewable energy
© 2019 One News Page Ltd. All Rights Reserved.
About us  |  Contact us  |  Disclaimer  |  Press Room  |  Terms & Conditions  |  Content Accreditation
 RSS  |  News for my Website  |  Free news search widget  |  In the News  |  DMCA / Content Removal  |  Privacy & Data Protection Policy
How are we doing? FeedbackSend us your feedback  |   LIKE us on Facebook   FOLLOW us on Twitter  •  FOLLOW us on Pinterest
One News® is a registered trademark of One News Page Ltd.