Curtain call on Cambodia's shadow puppets Puppet master Mann Kosal's troupe survived Location: Phnom Penh local interest dwindling over the years But with bans on travel and gatherings it has also lost its foreign audience Now Kosal has to pack up the theater as the government is taking over the company to ensure the survival of the ancient art (SOUNDBITE) (Khmer) CAMBODIAN SHADOW PUPPET MASTER, MANN KOSAL, SAYING:"I think about the 26 years period that I've worked here, and I love this art.
How can I take it out of my heart and when would I be able to forget it?
That was what I thought (to myself) when I posted my message on Facebook.
But now I feel relieved that the Ministry of Culture and Fine Arts accepted our request and gave us the solution." Courtesy: Sovana Phum Theater Organization Shadow puppets date back to the 7th century It was named a UNESCO intangible cultural heritage in 2005 with only five troupes remaining in the country
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
White House health experts are warning of a slow rise in the percentage of people testing positive for coronavirus in U.S. cities such as Boston, Chicago, Detroit and Washington and urged local leaders to remain vigilant to avoid a surge. Lisa Bernhard produced this report.
[NFA] Ohio Governor Mike DeWine said on Thursday he had tested positive for COVID-19 as part of a safety protocol to greet U.S. President Donald Trump when he arrived in Cleveland to visit a Whirlpool washing machine factory. This report produced by Yahaira Jacquez.
Although nail salons are reopening nationwide, COVID-19 is still very much an ongoing pandemic. In Washington, under the state's guidelines for personal service providers, that includes nail salons, clients "must self-screen for signs and symptoms of COVID-19 before arriving at the service provider location." But a nail technician named Taylor recently shared a since-removed Facebook post with a screenshot of a text-message conversation she says she had with a customer.
Rapper Wretch 32 joins a Black Lives Matter protest on the streets of Tottenham in north London. Campaigner Stafford Scott says they had no choice but to hold another demonstration to highlight racism in the police force. Report by Barnesj. Like us on Facebook at http://www.facebook.com/itn and follow us on Twitter at http://twitter.com/itn
As Princess Beatrice turns 32, we look back at an important year for the young royal. Report by Shoulderg. Like us on Facebook at http://www.facebook.com/itn and follow us on Twitter at http://twitter.com/itn
Lebanon's Prime Minister has told ITV News the people of Beirut have a "right" to be furious after the huge explosion which killed dozens and injured many thousands more. In his first interview since the deadly blast on Tuesday, Hassan Diab said people also had a right to be angry with politicians for what he called three decades of corruption in the country. Report by Blairm. Like us on Facebook at http://www.facebook.com/itn and follow us on Twitter at http://twitter.com/itn
Schools minister Nick Gibb has insisted the government will take "swift action" to deal with any spike in coronavirus transmission in particular areas of the country. His comments were made after Preston was added to the areas where households are banned from mixing indoors and in gardens due to a rise in Covid-19 cases. Report by Blairm. Like us on Facebook at http://www.facebook.com/itn and follow us on Twitter at http://twitter.com/itn