As trajectory of COVID-19 cases continues to surge, Maharashtra and Andhra Pradesh are recording over 10,000 cases daily. Andhra Pradesh has reported 2,06,960 cases so far. With 10,483 new cases, total tally of Maharashtra stood at 4,90,262. Total cases in India surpassed 20-lakh mark on August 7. 2,27,88,393 samples have been tested so far, according to ICMR.
Chief Minister of Andhra Pradesh, YS Jagan Mohan Reddy held a review meeting over COVID-19 situation in the state on August 07. Several state officials were also present in the meeting. The total number of COVID-19 cases in the state are 1,96,789 including 1,12,870 recoveries, 82,166 active cases while 1,753 deaths have been reported so far.
A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been published online in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target for the potential treatment. Otherwise, a medication effective against one strain would no longer be effective against another. The best candidates for this are conservative proteins, such as the SARS-CoV-2 virus main protease M pro. In addition to being resistant to mutations, M pro plays a major role in coronavirusreplication, which means that its inhibition (blocking its function) is able to slow down or even completely stop its reproduction inside the body.Usually, the process of docking, as with a port dock and a ship entering it, is used for molecular modelling in simple cases. Two molecules participate in docking. One is called a 'ligand' (here, it is a medicine), and the other one is 'receptor' (or active site) of the target protein, such as Mpro, which can be used to 'dock'. An effective drug docks with the active site, by covalent links, which makes the enzyme dysfunctional or destroys it. But classical docking does not work in SARS-CoV-2.To overcome this problem, chemists from HSE University and the Zelinsky Institute decided to use 'on-top docking', which they came up with shortly before the pandemic. 'We decided not to focus on the previously described active site, but to investigate the whole surface of M pro protein with many medications, hoping that the big calculation powers would return useful "dockings",' - said Igor Svitanko, the author of the article,Professor at the HSE Joint Department of Organic Chemistry with the RAS Zelinsky Institute of Organic Chemistry.
Dogs trained for jsut a week can sniff out the Sars-Cov-2 virus, according to new research. They can differentiate between samples from Sars-Cov-2 infectaded patiens and non-infected people. Dogs could be used in public areas like airports, sport events, borders or other mass gatherings. The research team was led by the University of Veterinary Medicine Hannove (TIHO) in cooperation with the German Army, Hannover Medical School & the University Medical-Center Hamburg-Eppendorf.
Credit: Cover Video STUDIO Duration: 01:01Published
Metabolic syndrome increases the risk of severe disease from a viral infection, according to a review of the literature performed by a team of researchers from St. Jude Graduate School of Biomedical Sciences and the University of Tennessee Health Science Center, both in Memphis. Metabolic syndrome is a cluster of at least 3 co-occurring conditions that raise the risk of heart disease, stroke and type 2 diabetes mellitus (T2DM). These conditions include excess abdominal fat, high blood pressure, excess blood sugar, abnormalities of lipids (including excess triglycerides and cholesterol), insulin resistance and a proinflammatory state. Multiple studies have shown that obesity is associated with increased severity of influenza A, higher viral titers in exhaled breath and prolonged transmission of the virus, according to the report. Changes in the viral population may abet the emergence of more pathogenic influenza variants, according to the report. Despite the fact that influenza vaccines generate robust antibody titers in obese subjects, obesity doubles the likelihood of developing influenza. As with influenza virus, the Centers for Disease Control and Prevention recently recognized obesity as a risk factor for severe illness caused by SARS-CoV-2.
Jharkhand government is concerned over the movement of people from Bihar in Jharkhand despite the lockdown. Chief Minister Hemant Soren said on July 16, "The movement of people still not stopped, Bihar government need to think on this matter." It is noted that, the Bihar government has enforced lockdown in the state from July 16 to July 31 in view of rising Covid-19 cases. Meanwhile, to tackle the spread of SARS-CoV-2, Jharkhand government is setting up a control room in the state, "There is very little role of doctors in this infection, this need nursing and hygienic environment," Soren added.
David Hasselhoff's classic show, "Knight Rider", is coming back. Deadline reports James Wan is attached to produce a new film adaptation of Knight Rider. The film will be produced through his Atomic Monster production company and Spyglass Media. Plot details for this latest installment are being kept under wrap. Gizmodo reports the project will be a present-day take that will maintain the anti-establishment tone of the original.
A man’s encounter with COVID-19 likely led to him experiencing life-threatening catatonia. Gizmodo reports Swedish doctors say it erased days of his memory. The man was able to recover without serious brain damage thanks to prompt treatment. However, the doctors warn that the man’s case may highlight a never-before-seen form issue. We don't know the extent of neurological complications that can be caused by the coronavirus.
In yet another high-profile instance of cybersecurity crime, a Twitter user on Thursday leaked 20GB worth of confidential Intel documents. The Twitter user says they received the documents from an anonymous hacker, and the files had been stored on a file-sharing service. Gizmodo reports that according to the leaker, the folder contains classified information under NDA, or a non-disclosure agreement. What is unknown at this time is what the files actually reveal.
In 2019, a Runner’s World survey found that 84% of women have said they experienced some kind of harassment that left them feeling unsafe. So, why in the world would anyone post their running routes on social media? According to Gizmodo, that's a terrible idea. Many apps allow people to access the times, locations, and sweaty selfies of complete strangers online. In fact, most of these running apps encourage this sort of social broadcasting.
Deadline reports that Tom Hanks is now once again in talks to play Gepetto in Robert Zemeckis’ remake of Disney’s Pinocchio. Insiders say negotiations are very early. Gizmodo reports Hanks read the script and reached out to Zemeckis to let him know he wants to do the film. Disney has always longed for Hanks to play the Geppeto. They approached him years ago when Paul King was attached to direct. That deal was never made. Hanks and Zemeckis’ have a long standing working friendship.